Abstract
(Neupro ) is indicated for use as monotherapy in the treatment of early-stage Parkinson’s disease or, in the EU, as an adjunct to levodopa across all disease stages. Transdermal rotigotine is an effective and generally well tolerated addition to the armamentarium for the control of Parkinson’s disease, with the once-daily transdermal patch system offering several practical advantages and the possible benefits of avoiding pulsatile dopaminergic stimulation. Transdermal rotigotine was superior to placebo in patients with early-stage and advanced Parkinson’s disease, although noninferiority to the oral dopamine agonists ropinirole or pramipexole was not consistently demonstrated. Additional active comparator trials would be of interest. In the meantime, transdermal rotigotine offers a convenient new treatment option for patients with Parkinson’s disease. Rotigotine has agonist effects at all dopamine receptors in vitro, with the greatest Pharmacological affinity for, and activity at, the dopamine D receptor subtype. It also interacts to Properties some extent with α - and α -adrenergic receptors, serotonin 5-HT and 2B 2C 1A 5-HT receptors, and σ receptors, and to a minor extent with monoamine trans- porters. The beneficial effects of rotigotine in the treatment of Parkinson’s disease are thought to be mediated via activation of D , D and
Brussels (Belgium), 25th December 2012 - The Japanese Ministry of Health, Labour and Welfare (MHLW) has approved Neupro® (rotigotine transdermal patch) for the treatment of Parkinson's disease (PD) and for the symptomatic treatment of moderate-to-severe idiopathic Restless Legs Syndrome (RLS) in adults.1 In 2002 Otsuka Pharmaceutical acquired.
Journal
CNS Drugs – Springer Journals
Neupro Rotigotine Transdermal Patch 2012 Best Review
- NEUPRO is a medication with the proven potential for RLS symptom relief. It is a patch that delivers the dopamine agonist rotigotine through the skin. With NEUPRO, your RLS symptoms are treated with one patch, once a day.
- How to use Neupro Patch, Transdermal 24 Hours. Read the Patient Information Leaflet if available from your pharmacist before you start using rotigotine and each time you get a refill. Learn how to.
Transdermal Patch Placement
Published: Aug 29, 2012